Interior to issue fracking rules in a few months (reuters)

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South Sudan rebels threaten Warrap state, call for evacuation (Reuters)

JUBA (Reuters) ? A rebel group in South Sudan threatened on Saturday to attack Warrap state to bring down the local government and called on the United Nations and residents to leave within three days.

The South Sudan Liberation Army, one of several rebel groups in South Sudan, said it would turn its attention to the state after earlier attacking Mayom town in neighboring oil-producing Unity state, also on the border on Sudan.

"Within few days, the people of Warrap will be liberated from abject poverty, corruption and abuse of human rights," it said in a statement.

"We would also advise the civilians to evacuate all towns and move to villages in order to be safe," it said.

The United Nations mainly runs humanitarian operations for food deliveries and aid to local people and Southern Sudanese coming from the north.

South Sudan became independent in July after a 2005 peace deal with Khartoum that ended decades of civil war, but the new nation has been struggling to end tribal and rebel violence that has killed around 3,000 people this year.

Rebel and tribal violence undermine stability in South Sudan struggling to build up state institutions. Several rebel militias are fighting government forces in remote parts of the country, which is roughly the size of France.

Officials in South Sudan said earlier on Saturday the SSLA had killed 15 people, including nine soldiers, and wounded 18 when attacking Mayom in the morning.

"We got attacked in Mayom town today by the militias from 6 to 7 a.m. The militia attacked the town, killed 15 and wounded 18," Unity state Information Minister Gideon Gatpan Thoar said. "More than 60 militiamen were killed."

Army spokesman Philip Aguer said: "It was indiscriminate, they didn't differentiate between civilians and the army. The killing included a doctor."

Aguer said Mayom was now under army control but the SSLA rejected that, adding in its statement: "Within four hours, SSLA forces also managed to capture Tomor town and they are now advancing toward Bentiu town."

(Reporting by Hereward Holland; Writing by Ulf Laessing; Editing by)

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/nm/20111029/wl_nm/us_sudan_south

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Siri port now talking to Apple servers, avoiding Cydia

A little cajoling from a clever developer got Siri talking to the iPhone 4 and the iPad, but Apple's tight-lipped servers kept the conversation effectively one-sided. The last-gen port was still missing something, and developer Steven Troughton-Smith knew where to find it: a jailbroken iPhone 4S. In an interview with 9to5mac, Troughton-Smith said that getting Siri to talk to Cupertino's data servers only took ten minutes after he had all of the pieces in place. Ready for your personal assistant port? Hold the phone, the process is a bit dodgy -- our hacking hero said that getting Siri on the older device is a 20-step process, and it requires files from the iPhone 4S that he says aren't his to distribute. When asked about distributing the hack over Cydia, Troughton-Smith said it was something he couldn't be a part of. On Twitter he suggested that a release would "anger the hive," but promised to post detailed notes on the hack after a iPhone 4S jailbreak drops.

Filed under: Cellphones

Siri port now talking to Apple servers, avoiding Cydia originally appeared on Engadget on Sun, 30 Oct 2011 03:34:00 EDT. Please see our terms for use of feeds.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/aMnvEqQ61Dw/

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Americans stay put amid economic downturn

WASHINGTON?? Yet another symptom of the economic downturn: Americans aren't moving.

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Young adults are staying put, often with their parents. Older people aren't able to retire to beachfront or lakeside homes.

U.S. mobility is at its lowest point since World War II.

New information from the Census Bureau highlights the continuing impact of the housing bust and unemployment on U.S. migration, after earlier signs that mobility was back on the upswing. It's a shift from America's long-standing cultural image of ever-changing frontiers, dating to the westward migration of the 1800s and more recently in the spreading out of whites, blacks and Hispanics in the Sun Belt's housing boom.

Rather than housing magnets such as Arizona, Florida and Nevada, it is now more traditional, densely populated states ? California, Illinois, Massachusetts, New York and New Jersey ? that are showing some of the biggest population gains in the recent economic slump, according to the data released Thursday.

Residents have been largely locked in place. Families are stuck in devalued homes and young adults are living with parents or staying put in the towns where they went to college.

"The fact that mobility is crashing is something that I think is quite devastating," said Richard Florida, an American urban theorist and professor at the University of Toronto's Rotman School of Management. He described America's residential movement as an important element of its economic resilience and history, from development of the nation's farmland in the Midwest to its coastal ports and homesteading in the West.

"The latest decline shows we are in a long-run economic reset and that we never really recovered ? we've just been stagnating along," Florida said.

About 11.6 percent of the nation's population, or 35.1 million, moved to a new home in the past year, down from 12.5 percent in the previous year. The current level of low mobility comes after the recession technically ended in mid-2009, beating a previous low of 11.9 percent in 2008.

It is the lowest in the 60-plus years that the Census Bureau has tracked information on moves, dating to 1948.

The share of people moving has been declining for decades, due in part to increases in two-income families that are more tied down by jobs and to an aging population that is less mobile. The peak for U.S. mobility came in 1951, when it hit 21.2 percent. The rate had leveled off at around 13 percent before falling off notably in 2008 during the recession.

Among young adults 25 to 29, the most mobile age group, moves fell to 24.1 percent from 25.9 percent in the previous year.

Longer-distance moves, typically for those seeking new careers in other regions of the country, remained largely flat at 3.4 percent.

The biggest drop-off occurred in local moves, down to 15.4 percent from 17.7 percent in 2010. It's a sign that young adults in the prolonged slump weren't even willing to venture outside their counties, continuing instead to live with relatives or on college campuses.

People most often cite a desire to live in a new home as the main reason for moving, as well as reasons of family or economy such as marriage or a new job. But analysts say with many young adults delaying marriage while struggling to find employment and aging baby boomers expressing financial worries about retirement, the current mobility freeze could continue for several more years.

An Associated Press-LifeGoesStrong.com poll this month found that more than half of baby boomers born between 1946 and 1964 say they are unlikely to move somewhere new in retirement; about 4 in 10 say they are very likely to stay in their current home throughout all of their retirement.

The annual growth of retirement-destination counties, typically in Sun Belt states such as Florida, Arizona and New Mexico, has fallen sharply since the recession that began in late 2007. It's down nearly half compared with the period 2000-2007, according to recent census data.

In all, the mid-decade housing boom and subsequent bust took a toll on virtually all age and race groups.

Homeownership declined in 47 states and the District of Columbia while the national ownership rate fell by its largest amount since the 1930s. Hispanics who moved and purchased homes in new destinations in the Southeast were hit especially hard, with bigger drops in average income and increases in poverty after low-wage construction jobs dried up in states such as South Carolina, North Carolina, Alabama, Kentucky and Tennessee.

In contrast, middle-class blacks from the North who migrated to Southern states such as Georgia, Florida and Texas fared better, maintaining higher incomes than African-Americans who remained in declining industrial centers such as Michigan and Ohio.

Other bright spots in the housing bust included urban, high-tech college meccas that are proving to be a draw for young, college-educated adults of all races and ethnicities.

The data covering 2008-2010 show that Raleigh, N.C.; the Texas cities of Austin, San Antonio and Houston; Denver; Pittsburgh; and Baltimore and Washington, D.C., had some of the biggest gains in residents. All of them tend to promise specialized tech jobs and hip lifestyles.

William H. Frey, a Brookings Institution demographer who reviewed the education and race data, said many of these cities will continue to attract new residents after the economy fully recovers. He said other cities must seek ways to diversify their industries, draw new investment and build partnerships with local universities to attract young talent, much like Pittsburgh has been striving to do after the collapse of its steel industry.

"Right now, the 'cool' cities are serving as way stations for the small number of adventurous young people who are willing to move in a down economy. But when the broader economy picks up, a much larger group of people will move to wherever the jobs spring up," Frey said, noting that people are staying put for now because they have to, not because they want to.

"We are now just in a lull, albeit a hyperextended one," he said.

Other findings:

?Texas posted increases in average income across all race groups even after the housing bust. The District of Columbia had the biggest overall gain in average income between 2005-2007 and 2008-2010 time periods, increasing 9 percent to nearly $60,000. Thirty-six states had declines.

?The district, New York, Connecticut, Louisiana, Mississippi, Texas, Alabama and California have levels of income inequality that rise above the national average. Broken down by large metropolitan areas, New York City, Miami, Los Angeles, Houston, Memphis, Tenn., New Orleans, San Francisco, and Birmingham, Ala., each had wider-than-average gaps between rich and poor.

?Across smaller areas of geography, Fountainhead-Orchard Hills, Md., just north of Hagerstown, had the greatest measured income inequality. Country Knolls, N.Y., near Albany, registered the least.

?Suburban and rural homeowners were more likely to stay put than others. Some 93.5 percent of the suburban and 93.7 percent of the rural population in owner-occupied units are residing in the same house as one year ago, up from the 2005-2007 time period, according to Kenneth Johnson, senior demographer at the University of New Hampshire.

?Renters were more mobile: Overall, 68.8 percent lived in the same rental unit one year ago.

John R. Logan, a sociology professor at Brown University, described consequences for mostly minorities should U.S. mobility stay frozen for extended periods. His research on neighborhood segregation has found that the average black or Hispanic household earning over $75,000 lives in a poorer neighborhood than the average white resident earning under $40,000.

"Being locked into place has its most severe effects on blacks and Hispanics, who are often segregated into disadvantaged neighborhoods regardless of their own incomes," he said. "Many middle-class homeowners in these neighborhoods have lost home equity, making it harder to move to communities with better schools and safer streets. Even the slow decline in black-white segregation that we've seen in the last 20 years will be hard to maintain under these conditions."

The census findings were based on the Current Population Survey as of March 2011, as well as comparisons of the 2005-2007 and the 2008-2010 American Community Survey to provide a snapshot of every U.S. community with at least 20,000 residents. Figures on income inequality come from a census analysis of survey data from 2005-2009.

___

Online:

www.census.gov

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45064895/ns/us_news-life/

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Contracts to buy homes fell 4.6 percent in Sept.

WASHINGTON (AP) ? The number of Americans who signed contracts to buy homes fell for the third straight month in September after the spring-and-summer peak buying season failed to entice new buyers.

The National Association of Realtors said Wednesday that its index of sales agreements fell 4.6 percent last month to a reading of 84.5.

A reading of 100 is considered healthy. The last time the index reached that high was in April 2010, the final month that buyers could qualify for a federal tax credit that has since expired.

Contract signings are usually a reliable indicator of where the housing market is headed. There's typically a one- to two-month lag between a contract and a completed deal.

But the Realtors group said a growing number of buyers have canceled contracts after appraisals showed that the homes were worth less than the buyers had bid. A sale isn't final until a mortgage is closed. That means more "pending" sales aren't turning into final sales.

"It is especially troubling given the big August decline in long-term interest rates," said Pierre Ellis, an analyst at Decision Economics.

Homes are the most affordable they've been in decades. Long-term mortgage rates are hovering at record lows near 4 percent. Prices in some metro areas have been cut in half. Still, sales in most areas remain weak.

In part, that's because loans are harder to get. Many lenders are requiring 20 percent down payments and strong credit scores to qualify.

Sales for previously occupied homes are on pace to match last year's 4.91 million sold, the fewest since 1997. In a healthy economy, Americans would buy roughly 6 million homes each year.

In September, sales of new homes rose after four straight monthly declines. But that was largely because builders had cut their prices in the face of depressed demand. This year is shaping up as the worst for new-home sales on records dating to 1963.

The number of people who signed home contracts had risen in both May and June before falling 7 percent over the past three months.

Contract signings fell across the U.S. September's index fell 2.1 percent in the West, 4.7 percent in the Northeast, 5.5 percent in the South and 6.2 percent in the Midwest.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-10-27-Pending%20Home%20Sales/id-c1e338d7452d4aaebee3c1a4691f4fe8

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Yeast model connects Alzheimer's disease risk and amyloid beta toxicity

Thursday, October 27, 2011
Using yeast cells, a team of Whitehead scientists in the lab of Whitehead Member Susan Lindquist investigated the harmful effects of amyloid beta (A?), a peptide whose accumulation in amyloid plaques is a hallmark of AD. Work by the lab indicates that A? disrupts normal cellular trafficking, with clathrin-mediated endocytosis being specifically vulnerable. Under normal conditions, the membrane bound receptor Ste3 (green) is subject to clathrin-mediated endocytosis and is trafficked to the cell?s vacuole (left). In A? expressing yeast cells, Ste3 is not localized to the vacuole, but is dispersed in foci throughout the cell, indicating that endocytic trafficking is perturbed (center). Expression of the yeast homolog of PICALM, one of the most highly validated human AD risk factors, restores normal trafficking in A?-expressing yeast, and Ste3 is again localized in the vacuole (right). Credit: Courtesy of Science/AAAS

In a development that sheds new light on the pathology of Alzheimer's disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the effects of a peptide toxic to nerve cells in the brains of AD patients.

The scientists, working in and in collaboration with the lab of Whitehead Member Susan Lindquist, established these previously unknown links in an unexpected way. They used a very simple cell type?yeast cells?to investigate the harmful effects of amyloid beta (A?), a peptide whose accumulation in amyloid plaques is a hallmark of AD. This new yeast model of A? toxicity, which they further validated in the worm C. elegans and in rat neurons, enables researchers to identify and test potential genetic modifiers of this toxicity.

"As we tackle other diseases and extend our lifetimes, Alzheimer's and related diseases will be the most devastating personal challenge for our families and one the most crushing burdens on our economy," says Lindquist, who is also a professor of biology at Massachusetts Institute of Technology and an investigator of the Howard Hughes Medical Institute. "We have to try new approaches and find out-of the-box solutions."

In a multi-step process, the researchers were able to introduce the form of A? most closely associated with AD into yeast in a manner that mimics its presence in human cells. The resulting toxicity in yeast reflects aspects of the mechanism by which this protein damages neurons. This became clear when a screen of the yeast genome for genes that affect A? toxicity identified a dozen genes that have clear human homologs, including several that have previously been linked to AD risk by genome-wide association studies (GWAS) but with no known mechanistic connection.

With these genetic candidates in hand, the team set out to answer two key questions: Would the genes identified in yeast actually affect A? toxicity in neurons? And if so, how?

To address the first issue, in a collaboration with Guy Caldwell's lab at the University of Alabama, researchers created lines of C. elegans worms expressing the toxic form of A? specifically in a subset of neurons particularly vulnerable in AD. This resulted in an age-dependent loss of these neurons. Introducing the genes identified in the yeast that suppressed A? toxicity into the worms counteracted this toxicity. One of these modifiers is the homolog of PICALM, one of the most highly validated human AD risk factors. To address whether PICALM could also suppress A? toxicity in mammalian neurons, the group exposed cultured rat neurons to toxic A? species. Expressing PICALM in these neurons increased their survival.

The question of how these AD risk genes were actually impacting A? toxicity in neurons remained. The researchers had noted that many of the genes were associated with a key cellular protein-trafficking process known as endocytosis. This is the pathway that nerve cells use to move around the vital signaling molecules with which they connect circuits in the brain. They theorized that perhaps A? was doing its damage by disrupting this process. Returning to yeast, they discovered that, in fact, the trafficking of signaling molecules in yeast was adversely affected by A?. Here again, introducing genes identified as suppressors of A? toxicity helped restore proper functioning.

Much remains to be learned, but the work provides a new and promising avenue to explore the mechanisms of genes identified in studies of disease susceptibility.

"We now have the sequencing power to detect all these important disease risk alleles, but that doesn't tell us what they're actually doing, how they lead to disease," says Sebastian Treusch, a former graduate student in the Lindquist lab and now a postdoctoral research associate at Princeton University.

Jessica Goodman, a postdoctoral fellow in the Lindquist lab, says the yeast model provides a link between genetic data and efforts to understand AD from the biochemical and neurological perspectives.

"Our yeast model bridges the gap between these two fields," Goodman adds. "It enables us to figure out the mechanisms of these risk factors which were previously unknown."

Members of the Lindquist lab intend to fully exploit the yeast model, using it to identify novel AD risk genes, perhaps in a first step to determining if identified genes have mutations in AD patient samples. The work will undoubtedly take the lab into uncharted territory.

###

Whitehead Institute for Biomedical Research: http://www.wi.mit.edu/index.html

Thanks to Whitehead Institute for Biomedical Research for this article.

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Source: http://www.labspaces.net/114701/Yeast_model_connects_Alzheimer_s_disease_risk_and_amyloid_beta_toxicity

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89% The Lion King (In 3D)

All Critics (95) | Top Critics (15) | Fresh (95) | Rotten (10) | DVD (53)

The story line is a Joseph Campbell hero-quest so stripped down to its basics as to become dull.

A computer-animated scene featuring a stampede of wildebeest is positively breathtaking.

The Lion King, more than any of the recent wave of Disney animated features, has the resonance to stand not just as a terrific cartoon but as an emotionally pungent movie.

The result is a step toward multiculturalism and ecological correctness, though not without a certain amount of confusion.

A crown jewel of modern Disney animation.

More so than the exuberant movie miracles that came before it, this latest animated juggernaut has the feeling of a clever, predictable product.

It's not hard to understand why The Lion King's good-vs.-evil adventure and high-spirited comic passages haven't lost their appeal. [Blu-ray]

It's an attractive film but altogether less interesting and more conventional than the Pixar productions that now dominate Disney's animated output.

"Hakuna Matata" would mean never having to be subjected to The Lion King ever again, much less having Simba's growing pains coming at your face in 3D.

It does exactly what it says on the tin.

Feel the love tonight. And see the colours, too.

The 3D technology adds some eye-popping moments but the best thing about this reissue is the chance for a new generation to see a modern classic on a cinema screen.

There are no gimmicks and the big emotional moments are almost entirely untouched.

However crass Disney's motivation may have been in rereleasing the film... it's cheering to see that... people still want to see great movies on a big screen with big sound...

Well worth another look, though it's a pity they're saving the newly made bloopers for the upcoming Blu-ray.

It didn't really need the 3D, but it's still a stunning, glorious family film, with the third dimension or otherwise.

While the core ideology behind The Lion King is extremely problematic and stands out even more today than it did in 1994, there is still much to admire about the film.

It's a wonderful treat to revisit and the 3-D is beautifully utilised, but it's perhaps not the classic that Disney purports it to be.

Art History stands out as one of Joe Swanberg's most visually and conceptually accomplished experiments.

Is the 3D version superior to the 2D version? No. Is the film still magnificent? Yes.

While "The Lion King" is one of the best Disney movies of all time, "The Lion King 3D" is a manipulative exploitation to bring paying parents back with their kids merely through the sexiness of today's 3D fad.

More Critic Reviews

Source: http://www.rottentomatoes.com/m/the_lion_king/

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