Thursday, July 25, 2013

Apple Working On Location-Aware Battery Management For iPhone

small (12)Apple has been tinkering with ways to make the iPhone better at managing battery life intelligently based on usage pattern, a new patent filing published by the USPTO today (spotted by AppleInsider) reveals. The application describes a system that learns your habits, evaluates how much power is needed between your usual charges and does everything it can to keep the phone running when you're away from power sources.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/lGS4XSeSud8/

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Sunday, July 21, 2013

Samsung updates Galaxy S3 and Note 2, not the Android Jelly Bean 4.2 yet

Samsung launches new ?online store? that would compete with Google Play Store, the official online store of the Android ecosystem.?

JULY 21, 2013, 7:09 PM. Article by Raphael Labuguen.

Samsung Electronics is updating its Galaxy S3 and Note 2 devices today, as reported by Android Police, but it isn?t for the much anticipated Android Jelly Bean 4.2.2 yet. The new upgrade is for the Samsung Hub, the updated version of the company?s own content store which would merge both the Media and Music hubs into one catalog. It makes sense because it?s quite obvious that Samsung wants to create its own ecosystem within Android that would allow the Korean-based phone giant to generate revenue even after the phone purchase.

Source: http://www.popherald.com/news/20130721/samsung/galaxy-s3-note-2-s4-new-android-store.php

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Saturday, July 20, 2013

Six current college players join O'Bannon v. NCAA

By Jerry Hinnen | College Football Writer

Clemson's Darius Robinson has joined the Ed O'Bannon lawsuit against the NCAA. (USATSI)
Clemson's Darius Robinson has joined the Ed O'Bannon lawsuit against the NCAA. (USATSI)
Judge Claudia Wilken recently told the plaintiffs in the Ed O'Bannon lawsuit that if they wanted to proceed with their class-action lawsuit against the NCAA -- one that could force the NCAA and its member conferences to split revenues with their athletes -- they would have to add at least one current athlete to the plaintiffs' roster.

The O'Bannon attorneys added six Thursday, all of whom are seniors at BCS schools: Vanderbilt linebacker Chase Garnham; Clemson cornerback Darius Robinson; linebacker Jake Fischer and kicker Jake Smith from Arizona; and tight end Moses Alipate and wide receiver Victor Keise of Minnesota. They join a roster of 16 former NCAA athletes, including UCLA basketball player O'Bannon, already listed as plaintiffs.

"These athletes are incredibly brave. They are well-aware of the risks of standing up to the NCAA, and yet they felt that this was the right thing to do," the lead attorney for the plaintiffs, Michael Hausfeld, said in a statement.

"This is definitely something that I would love to get involved in," Robinson told Sports Illustrated's Andy Staples, "because I really do believe in it."

Robinson has started six games each of the past two seasons for the Tigers and told SI he had zero doubt the Clemson cornerback labeled "No. 21" in the EA Sports NCAA Football video game franchise represented him.

"That's me all the way," he said. "It's as close as it gets. Size, ratings. I don't have the best hands as a corner, so I always drop interceptions on the video game."

EA Sports is also named in the lawsuit, which began as O'Bannon's attempt to claim a share of the revenues from a video game, which featured his likeness and has since expanded into a potential class-action suit that could cause major change across college athletics. EA Sports alleged use of real players as models for their virtual counterparts -- with the NCAA's supposed blessing -- is a critical issue for the lawsuit.

The NCAA announced this week it was declining to renew its licensing contract with EA Sports, though the company plans to continue the series under a different name.

"It's admission of a practice that goes to the heart of the contention that the NCAA believes it is above the law," Hausfeld said.

An NCAA spokeswoman told the Associated Press it would not comment on the additions of the new plaintiffs until it has time to read the amended complaint.

Like Robinson, Fischer (who led Arizona in tackles in 2012) and Garnham are expected to be major contributors for their teams; Smith is expected to compete for the Wildcats' starting kicking job. SBNation writes that all four of those players appear to have been models for players in the current NCAA Football game, noting that "Smith and Garnham are identical in height, weight, and uniform number, while Fischer's avatar is a few pounds lighter than the real thing."

While the two Minnesota players appear to be absent from the game, Staples notes that their additions to the suit could be related to a release form Big Ten athletes are required to sign.

Topics: Chase Garnham, Darius Robinson, Jake Fischer, Jake Smith, Moses Alipate, Victor Keise, NCAA, Arizona Wildcats, Clemson Tigers, Minnesota Golden Gophers, UCLA Bruins, Vanderbilt Commodores, NCAAF

Eye on College Football is maintained by the four handsomest men to ever handsome: Tom Fornelli, Jerry Hinnen, Chris Huston, and Chip Patterson. Follow Eye on College Football on Twitter, discover the meaning of life.

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Source: http://feedproxy.google.com/~r/cbssportsline/home_news/~3/RI9MxpK_EQ0/six-current-players-join-obannon-suit-against-ncaa

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Friday, July 19, 2013

Business Networking With Dr. Ivan Misner ? Business Networking ...




In this short video, referral marketing expert Tom Fleming and I explain what networking ?up? is all about and why it?s imperative to the success of your business that you focus on networking up. Though our natural instinct is often to stay firmly planted in our own comfort zone by associating with peop...


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I?ve done quite a few video blogs with Tiffanie Kellog and there?s a very good reason for that . . . she is an outstanding Referral Institute? Trainer, Consultant, & Speaker and she has an unending supply of highly useful ideas and comments to offer. In this video, I talk with Tiffanie about the power of...


A few weeks ago, I was sitting in an airport waiting for my plane to arrive and I struck up a conversation with the young man sitting next to me.? He was wearing a nice suit, carrying a laptop, and appeared to be traveling on business so I asked him if he happened to be traveling to the same business event that I was.?...


When you?re at a busy networking event, sometimes it?s easy to fall into the trap of not giving people your undivided attention.? However, making every effort to avoid that trap and to, instead, be fully present and focused on each conversation you have will no doubt help you make a huge impression on people...


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Source: http://businessnetworking.com/

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nicole sherzinger x factor auditions london

X FACTOR judge Nicole Scherzinger has turned up the heat in sweltering London in a black and white optical illusion dress and pink heels.

The X Factor judge was at the final day of the ITV show's auditions at at Wembley Arena.

Earlier today she told fans on Twitter: "Last day of XF auditions-I'm wearing Finders Keepers dress, @pedrogarcia shoes and @MFPepe jewellery."

Nicole was joined by fellow judges Louis Walsh, Gary Barlow and Sharon Osbourne.

Nicole Scherzinger

Shamazing ... Nicole Scherzinger

Lia Toby/Wenn

Louis donned shades and a plum jacket over a white shirt and jeans.

Take That star Gary Barlow ? who is rumoured to be quitting the programme after this series ? wore a khaki jacket over dark trousers.

Xtra Factor host Caroline Flack wore a printed skater dress.

X Factor judge Sharon Osbourne

Mrs O ... X Factor judge Sharon

She wrote on Twitter: "I'm so hot I feel like I'm wearing curtains."

Former Pussycat Dolls star Nicole, who was known for her quirky catchphrases on the show last year including "shamazing" recently declared that she has no friends in London.

LA-based Nicole said: ?I don?t have anyone here, I don?t have my family, I don?t even have any friends here. My publicist is my closest friend.

Louis Walsh

Long-time X Factor judge ... Louis Walsh

?It gets lonely but I?m working all the time.

?You just make those sacrifices and they made me feel so at home last year. It is hard but you always make those sacrifices and it?s worth it.?

Gary Barlow

Looking cool in shades ... Gary Barlow

Last year she relied on British F1 star Lewis Hamilton and his family for companionship when she wanted to socialise away from The X Factor.

However, Nic and Lewis split last month after five years because their hectic schedules left little time for love.

Caroline Flack

Prints charming ... Caroline Flack

Source: http://www.thesun.co.uk/sol/homepage/showbiz/tv/x_factor/5021413/nicole-sherzinger-x-factor-auditions-london.html

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Thursday, July 18, 2013

Shareholders voting on $24.4 billion Dell buyout

ROUND ROCK, Texas (AP) ? Dell shareholders are voting Thursday on founder Michael Dell's plan to take the slumping computer maker private in hopes of engineering a turnaround away from Wall Street's glare.

In a sign that the vote could be close, a special committee of the company's board sent a letter to shareholders emphasizing its opposition to a rival plan from activist investor Carl Icahn. Dell Inc. also said Thursday's meeting could be adjourned quickly without a formal vote to give the board more time to round up support for the $24.4 billion buyout offer from Michael Dell and other investors.

The vote was scheduled at a special shareholders meeting at the company's headquarters in Round Rock, Texas.

Supporters believe Dell Inc. stands a better chance of turning around if it can make long-term strategic decisions without worrying about meeting Wall Street's quarter-to-quarter expectations. But some big investors have already signaled opposition to the bid. Icahn believes the offer undervalues the company.

The company's decision to go private is a reflection of the tough times facing the personal computer industry as people delay replacing traditional computers and spend their money instead on the latest smartphones and tablets. PC sales have been falling, and tablets are expected to outsell laptops this year.

Michael Dell, who is Dell's CEO, is hoping to evolve the company into a more diversified seller of technology services, business software and high-end computers ? much the way IBM Corp. had successfully transformed itself in the 1990s.

On Tuesday, Dell's special committee said Icahn could have trumped the Michael Dell group's $13.65-per-share offer, but instead submitted a recapitalization plan that it called risky and short on details. Icahn's plan calls for rewarding shareholders with some cash now, but leaving about a third of the shares outstanding for shareholders to benefit from a successful turnaround. Icahn and his Southeastern Asset Management fund own a combined 13 percent of Dell.

"I believe it's a very, very close vote," said Patrick Moorhead, a technology analyst in Austin. "Institutional investors usually let a company know where they stand, so you can imagine a war room where (Dell advisers) are counting votes."

In corporate elections like this, shareholders can change their vote right up to the last minute. Michael Dell's task is made more difficult by an agreement that he would not cast his shares, which represent about 16 percent of the company's stock. That means the board needs slightly more than 42 percent of Dell's outstanding stock to accept Michael Dell's offer to get the deal done.

If Dell delays the vote because it doesn't have enough support, analysts say Michael Dell's group might sweeten his offer.

In an open letter released Wednesday, Icahn called for a vote Thursday regardless of the outcome: "Can you imagine a political election contest where one side could push off the election to wait for a better day to hold the election ? a date when it is hoped they might do better in the vote than they would have done on the originally scheduled election date?"

It would have been hard to imagine the company bearing Michael Dell's name facing this situation a decade ago, when it was riding high and leading the world in PC sales.

That was before the shift in how people engage with technology. Although the company has branched out into servers, storage devices and services, it is still heavily dependent on PCs and has suffered from the rise of smartphones and tablet computers. Last week, research firm IDC said worldwide PC shipments fell 11 percent in the April-June period, compared with a year earlier. That followed a 14 percent decline in the first three months of the year, the steepest quarterly drop since IDC started keeping records in 1994.

Dell shares have never recovered from their split-adjusted peak of nearly $60 during the dot-com boom in 2000. They were at a three-year high of around $18 in February 2012, when they started sliding again in the face of weakening PC shipments. Michael Dell began talking with potential partners about a private buyout even before the shares hit a low of $8.69 in November.

Rumors of a deal sent the shares higher before the board announced the agreement with Michael Dell and other investors on Feb. 5. A four-member special committee of the Dell board recommended that shareholders take the buyout, saying that it minimized their risk and gave them an all-cash payment at a premium over the share price before news of a possible deal leaked.

The committee said that it had wrangled six price increases from the group and that despite contacting dozens of other potential buyers, no superior offers emerged. One possible buyer, private equity firm Blackstone Group LP, dropped out in April, citing Dell's "rapidly eroding financial profile."

Icahn and Southeastern Asset Management have said that the buyout offer undervalues Dell, an opinion that has been echoed publicly by at least four more of Dell's top 20 shareholders. Icahn has proposed that the company buy back 1.1 billion shares at $14 each and added another element last week that will give stockholders warrants to buy additional shares. He has valued his plan at $15.50 to $18 per share.

If Icahn and Southeastern succeed in defeating the private-buyout offer, they would seek to replace the Dell board with their own slate of candidates and put their plan in effect. Icahn plans to oust Michael Dell as CEO, but hasn't said whom he has in mind to run the company.

Michael Dell's group got a boost when that offer was endorsed by three big shareholder-advising firms.

One of them, Glass, Lewis & Co., said it sympathized with those who believe the buyout offer was too low, "especially considering that many of the unhappy shareholders are long-term investors in Dell who likely purchased the stock at higher average prices" than $13.65. Still, the firm said, the certainty of a cash payout was better than the risk in continuing to hold Dell shares, which it said would fall "significantly" if the buyout is rejected ? maybe by nearly half.

Dell's stock fell 14 cents, or 1.1 percent, to close Wednesday at $12.88, below the $13.65 offered in the buyout. That's an indication that investors aren't holding out for a higher bid. Some analysts fear the stock will sink below $9 again if the deal with Michael Dell falls apart.

Michael Dell, the company's largest shareholder, is throwing in all of his stock and $750 million of his $16 billion fortune to help finance the sale to a group led by the investment firm Silver Lake. Dell's stock-and-cash contributions to the deal are valued at about $4.5 billion.

Software maker Microsoft, which counts Dell among its biggest customers, is backing the deal by lending $2 billion to the buyers. The remaining money to pay for the acquisition is being borrowed through loans arranged by several banks, saddling Dell with more than $15 billion in debt that could raise doubts about its financial stability among its risk-averse corporate customers.

The sale is structured as a leveraged buyout, which requires the acquired company to repay the debt taken on to finance the deal. Dell's sale is the second-highest-priced leveraged buyout of a technology company, trailing the $27 billion paid for First Data Corp. in 2007.

The Dell story is now famous: A 19-year-old started a business in 1983 by selling computer disk drives from his dorm room at the University of Texas at Austin. Soon he was assembling computers and undercutting conventional retailers on price. He then raised $30 million by taking the company public in 1988. Dell went on to change the PC business with low costs, customized orders and direct sales ? first over the phone and later the Internet. The CEO climbed the ranks of the richest Americans.

In 2004, when Dell stepped aside as CEO, sales topped $40 billion a year and were on their way to more than $60 billion. Dell returned as CEO in 2007, after the company had fallen behind Hewlett-Packard Co. as the world's largest PC maker and after it endured an accounting scandal that resulted in a $100 million corporate penalty and Dell himself paying $4 million. The company's stock is down by more than 40 percent from where it stood when Dell returned for his second stint as CEO.

Now 48, Dell is seeking to turn the company around away from the glare of Wall Street and the demand for short-term, next-quarter results that investors demand from public companies. He would build upon the company's recent efforts through acquisitions to get into more-profitable lines including business software, network security and consulting.

Cindy Shaw, a technology analyst in San Francisco, said shareholders should take the $13.65 and get out. She remains skeptical about the company's ability to reinvent itself.

"The proposed strategy isn't substantially different from plans that haven't worked since Michael came back as CEO six years ago," Shaw said. In her view, the company lacks speed and panache in pursuing openings created by new technology, but Dell wants to secure his reputation and "really believes he can turn this around."

Moorhead was more upbeat and said that getting away from Wall Street's obsession with short-term results would help.

"It could take five or six years to switch from a PC maker to an end-to-end enterprise IT player," he said. "I have a lot of confidence in Michael Dell's ability to lead this company's transformation."

Source: http://news.yahoo.com/shareholders-voting-24-4-billion-dell-buyout-200537800.html

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Wednesday, July 17, 2013

Moissanite and Recycled Sterling Silver Engagement, Wedding, or Everyday Ring, Made To Order by mcfarlanddesigns

If you're looking for plenty of style and sparkle on a budget, this ring is a good choice for you! A sparkly 6mm moissanite (equivalent in size to a 0.84 carat diamond) sits in a handmade bezel embellished with beaded wire on a coordinating 4mm wide band. All of the metal used in this ring's construction is sterling silver from recycled sources with a subtly brushed matte finish.

Please let me know what size you need when you place your order, and allow 3-4 weeks for fabrication of this custom-made piece.

I'm now offering an optional upgrade to Forever Brilliant moissanite in this design. You can read more about this option, and see photos and pricing, on my blog: http://mcfarlanddesigns.blogspot.com/2012/08/forever-brilliant-moissanite-upgrades.html ; if you would like to upgrade this ring to Forever Brilliant, please let me know in the 'message to seller' field during checkout and I will send a Paypal money request for the additional amount due.

If you're not familiar with moissanite, allow me to blather on a bit regarding what I've learned about this amazing material. Moissanite was originally born from a meteorite over 50,000 years ago, and was first discovered by Dr. Henri Moissan in 1893 in material collected from a meteor crater in Arizona. These incredibly brilliant sparkling crystals might have been considered "diamonds from space," but Dr. Moissan's research actually identified them as a new mineral find - silcon carbide, whose chemical composition is SiC (diamonds are made from carbon). This stunning jewel is extremely rare, and almost impossible to find in nature. So rare, in fact, that the dream of using it in jewelry was an impossibility until man discovered a way to create and craft these incredible silicon carbide crystals here on Earth.

With more fire than any popular gemstone (including diamond), no other stone or jewel compares to Moissanite. In fact, fire can be measured scientifically and moissanite has nearly 2.4 times the fire of diamond. Moissanite also has 10% more brilliance and luster than diamond. Proven to be harder than ruby, sapphire or emerald and second only to diamond, moissanite is also extraordinarily heat resistant, durable, and tough. It is extremely resistant to scratching, abrasion, breaking and chipping. And because these phenomenal stones are grown in a laboratory, you don't have to worry about the ethical problems involved with harvesting diamonds and other mined gems.

Pretty cool, huh? :-)

Due to the value of this piece, shipping costs have been adjusted to include insurance within the United States. I do offer international shipping; if you live outside the US, please contact me for a quote specific to your location. Due to the lack of availability of insurance through the US postal service for international packages, I use FedEx when shipping overseas; this is a more expensive but far safer option. International buyers, please be aware that you are solely responsible for any duties/taxes that your country may charge on imported goods.

As is all my jewelry, this piece is vegan, meaning no animal products (pearls, silk, leather, etc.) were used in its construction.

I accept PayPal, money orders, checks, and credit cards (please call me at 707-633-6340 if you would like to initiate a credit card payment outside of Paypal).

Source: http://www.etsy.com/listing/126517693/moissanite-and-recycled-sterling-silver

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Tuesday, July 16, 2013

World powers hope to resume Iran talks quickly

BRUSSELS (Reuters) - World powers hope to resume negotiations with Iran over its disputed nuclear program "as soon as possible", the European Union's foreign policy chief Catherine Ashton said on Tuesday.

Ashton, who oversees talks with Iran on behalf of the six powers, met senior diplomats from the United States, Russia, China, France, Britain and Germany in Brussels on Tuesday to discuss the future of the negotiations.

The last round of nuclear talks, held in April in Kazakhstan, failed to yield a solution to the decade-old standoff, and diplomacy has been on hold since then because of a presidential election in Iran last month.

Ashton said the six powers were waiting for Tehran to nominate a team of negotiators after the election, won by Hassan Rouhani.

"We very much hope that will be soon and we look forward to meeting with them as soon as possible," she said in a statement.

The six powers suspect Iran is seeking the means to make atom bombs and have demanded it suspends its most sensitive nuclear work. Tehran denies any military intentions and says its work has purely peaceful purposes such as medical research and energy generation.

(Reporting by Justyna Pawlak; Editing by Adrian Croft and Robin Pomeroy)

Source: http://news.yahoo.com/world-powers-hope-resume-iran-talks-quickly-134956689.html

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Friday, July 12, 2013

NBA executive VP Stu Jackson to step down Aug. 1, Rod Thorn to take his place

NEW YORK ? Executive vice president of basketball operations Stu Jackson is leaving his position at the NBA on Aug. 1, and Rod Thorn will return to the league office as president of basketball operations, the league said Wednesday.

Jackson spent more than 13 years at the league. In his current position, he is in charge of all rules, conduct and discipline on the court. He has been involved in college or pro basketball for more than three decades, was chairman of the NBA?s Competition Committee, and served on FIBA?s Competition Commission and USA Basketball?s Board of Directors.

?Stu has made enormous contributions to the NBA over the past 13 years,? NBA Commissioner David Stern said Wednesday in a statement. ?He informed Adam Silver, Joel Litvin and me some months ago that after a long and distinguished career at the league he felt that this was the appropriate time to step down. We thank Stu for a job very well done, including assisting with the transition to Rod, and wish him the best in his future endeavors.?

Thorn previously spent 14 seasons at the NBA office and has been a successful team executive with Chicago, New Jersey and Philadelphia. He drafted Michael Jordan with the Bulls and was Executive of the Year with the Nets.

?As a player, coach, general manager, league vice president and team president, Rod has been a member of the NBA family for decades, and his basketball knowledge and team relationships are unparalleled,? Stern said. ?We are fortunate that his talents are available to serve the league at this time.?

Thorn will oversee both basketball and referee operations. Kiki VanDeWeghe, the senior vice president of basketball operations, and Mike Bantom, the executive vice president of basketball operations, will report to Thorn.

Source: http://www.nj.com/sixers/index.ssf/2013/07/nba_executive_vp_stu_jackson_t.html

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Tuesday, July 2, 2013

Michael Jackson Had Child Sex Alarm Installed, Wade Robson Claims

Source: http://www.thehollywoodgossip.com/2013/07/michael-jackson-had-child-sex-alarm-installed-wade-robson-claims/

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Party outweighs protest after Brazil Confederations Cup victory

By Pedro Fonseca

RIO DE JANEIRO (Reuters) - Small skirmishes between police and protesters did little to disrupt the festive atmosphere around the close of a major international soccer tournament that has been the backdrop for the biggest mass demonstrations to sweep Brazil in 20 years.

Police clashed with a few belligerent protesters during a small demonstration outside Rio de Janeiro's Maracan? stadium late Sunday. Inside, Brazil's national team, cheered on by a thunderous hometown crowd, shut out world champions Spain 3-0.

The surprise victory marked a celebratory end to the Confederations Cup, a two-week tournament that has otherwise been overshadowed by the rapid and unexpected wave of recent discontent in Latin America's biggest country. The Confederations Cup is considered a warmup to the much-bigger World Cup, which Brazil will host next year.

Authorities deployed about 10,000 police and other security forces for the game after big demonstrations disrupted some matches during the tournament. Though uneventful marches proceeded peacefully earlier in the day, police officers fired teargas Sunday evening to disperse a small group of protesters.

At least two police officers were injured, one burned by a Molotov cocktail in the leg, the other by a blow to the head. Six protesters also suffered minor injuries, local media reported.

Sunday's tensions were the latest in a series of protests unfolding as Brazil confronts problems following a near decade-long economic boom. Brazilians have taken to the streets in recent weeks to protest poor public services, inflation, rising crime and a host of other ills.

The marches, which drew over 1 million protesters in more than 100 cities at their peak this month, have used the ongoing soccer tournament as a stage from which to vent their grievances. Many Brazilians are outraged that the country is spending about $14 billion to host the World Cup at a time when schools, hospitals, roads and public security are in dire need of investment.

President Dilma Rousseff, whose approval ratings have plunged since the protests began, was initially expected to attend Sunday's game - a major event in soccer-crazed Brazil. But, taking note of the discontent of voters, she decided not to attend after she was booed at the tournament opener in Brasilia.

On Saturday, polling firm Datafolha said Rousseff's approval rating sank by 27 percentage points in the last three weeks. Though the numbers fell from what had been consistently high ratings, the precipitous drop suggested that the demonstrations could pose a serious threat to her re-election bid next year.

(Additional reporting by Tatiana Ramil. Writing by Paulo Prada. Editing by Todd Benson, Christopher Wilson and Stacey Joyce)

Source: http://news.yahoo.com/party-outweighs-protest-brazil-confederations-cup-victory-011343435.html

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The Bachelorette Recap: Running Of The Bulls

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New regulatory autism gene discovered

July 1, 2013 ? A new study by Valerie Hu, Ph.D., professor of biochemistry and molecular medicine at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), reports that RORA, a novel candidate gene for autism discovered by her group in a 2010 study, regulates a large number of other genes associated with autism.

"We are focusing on this gene, in part, because this gene can act as a master regulator of other genes," said Hu, whose study was published in the journal Molecular Autism. "Called nuclear hormone receptors, they are capable of activating or suppressing other genes in the genome. The question was which specific genes are regulated by RORA."

Hu and co-author, Tewarit Sarachana, Ph.D., a former doctoral student in the molecular medicine doctoral program at SMHS, found that RORA encodes a protein that can regulate the expression of more than 2,500 other genes. Of these 2,500 genes, many are known to be involved in neuronal development and functions, and 426 of RORA's gene targets are already listed in AutismKB, a database of known autism candidate genes.

To identify genes regulated by RORA, Hu and Sarachana used chromatin immunoprecipitation (ChIP) with an anti-RORA antibody followed by whole-genome promoter array (chip) analysis. This genome-wide ChIP-on-chip analysis of target genes of RORA, as well as additional methods of validation, confirmed that RORA transcriptionally regulates the genes A2BP1, CYP19A1, HSD17B10, ITPR1, NLGN1, and NTRK2, such that when RORA levels are cut in half, all six genes also go down in their expression. The expression levels of these six genes are also reduced in RORA-deficient postmortem brain tissues from individuals with autism relative to that of age-matched unaffected controls.

"We see it as a domino effect, where RORA is a particularly shaky domino," said Hu. "If knocked over, it can also knock down a whole bunch of other genes, except that it's not just a single chain of events. There are multiple chains of events, leading to massive disruption of gene expression in autism."

A 2011 study by Hu's group revealed that RORA has the potential to be under negative and positive regulation by androgen and estrogen, respectively, suggesting that RORA may also contribute to the male bias of autism spectrum disorder.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/8wCLBqIShro/130701135034.htm

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Monday, July 1, 2013

Brahmin Theo iPad/Tablet Bag review

Right after I wrote my recent news item about the Theo iPad Bag from Brahmin, I set about finding one for myself. ?I promptly ordered the bag in the crocodile-embossed leather in Pecan. ?The bag arrived recently. ?Is it everything I hoped? All images can be clicked for an enlarged view. The Theo bag is [...]

Source: http://the-gadgeteer.com/2013/06/30/brahmin-theo-ipadtablet-bag-review/

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University of Michigan activates antimatter 'gun,' cartoon supervillians twirl moustaches anew

Scientists create tabletop antimatter 'gun,' cartoon supervillians twirl mustaches anew
At the University of Michigan, an international team of physicists has begun experimenting with its tabletop-sized super laser, modding it into an antimatter "gun." It's not quite a black hole-firing pistol, but we're slightly terrified nonetheless. Up until now, machines capable of creating positrons -- coupled with electrons, they comprise the energy similar to what's emitted by black holes and pulsars -- have needed to be as large as they are expensive. Creating these antimatter beams on a small scale will hopefully give astrophysicists greater insight into the "enigmatic features" of gamma ray bursts that are "virtually impossible to address by relying on direct observations," according to a paper published at Arvix. While the blasts only last fractions of a second each, the researchers report each firing produces a particle-density output level comparable to the accelerator at CERN. Just like that, the Longhorns/Wolverines super-laser arms-race begins again.

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Via: Gizmodo, PhysOrg

Source: Arvix

Source: http://www.engadget.com/2013/06/30/university-michigan-antimatter-gun/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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